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An Introduction to the Endocannabinoid System

An introduction to the endocannabinoid system

An Introduction to the Endocannabinoid System:

The concept of the endocannabinoid system (ECS) wasn’t introduced until the late 1980s. A study in 1988 led scientists to discover a receptor located in a mammal’s brain that responded to cannabis. Eventually, in March of 1992, a Czech scientist named Lumír Hanuš went on to discover the first known endocannabinoid in the human brain: anandamide. Endogenous cannabinoids such as anandamide function as neurotransmitters because they send chemical messages between nerve cells throughout the nervous system.

The first studies involving the endocannabinoid system and anandamide have laid the foundation for research on CBD and how it interacts within the human body. We have found that the endocannabinoid system is essentially a network that controls processes by way of endocannabinoid messaging. The three main components that make up the endocannabinoid system are cannabinoid receptors, endocannabinoids, and metabolic enzymes. Homeostasis, or a balance within the body, is the perceived primary goal of this system.

Cannabinoid Receptors

Cannabinoid receptors can be found on the outer surface of cells and are “monitoring” the conditions that take place outside of the cell. CB1 and CB2 are the two main types of cannabinoid receptors. Each type of receptor exists in a different part of the body within the endocannabinoid system. Nerve cells primarily contain CB1 receptors, while CB2 receptors are mostly found in the immune system.

Endocannabinoids

Endocannabinoids are the chemical compounds that interact with the cannabinoid receptors within the endocannabinoid system. Our bodies naturally produce Endocannabinoids, while phytocannabinoids, like CBD, are chemical compounds from plants. Since CBD is a cannabinoid, numerous receptors within our endocannabinoid system interact with CBD.

Metabolic Enzymes

The endocannabinoid system has specific metabolic enzymes. FAAH and MAGL are two of the main enzymes. These enzymes ensure endocannabinoids are utilized and are broken down once they are used.

FAAH breaks down anandamide, while MAGL breaks down 2-AG. It is believed that these metabolic enzymes are more successful at breaking down endocannabinoids that naturally occur within our body, and are less effective when working with plant cannabinoids. Further, it is suspected that CBD inhibits the FAAH enzyme from breaking down anandamide, leading to a greater abundance of endocannabinoids.

Future Research

Since its discovery in 1988, our knowledge of the endocannabinoid system has expanded. However, more research is necessary to understand this intricate and fascinating system. We will keep you up to date on any new findings and research as it becomes available.


Have any questions about CBD or the endocannabinoid system? Feel free to send us a message or leave a comment below!

One Reply to “An Introduction to the Endocannabinoid System”

  1. I am a 65-year-old pharmacist from Charlotte North Carolina I have stood on my feet for over 45 years and played competitive tennis for about as long I have had Four major back surgeries and fusion from my L3 down I had had my S I joint Fused, my performis released I have had my right hip replaced and my left knee meniscus repaired …in other words I am a mess.I have been a pain management patient for over 10 years as a pharmacist I needed to keep opioids at a minimum. I think God I found viridipharm. I was very skeptical about Cbd at first but results are what matter I really don’t think I would’ve ever had the first back surgery if Cbd had been available then I currently use the oil in the 6000 which means I have about 10 mg per drop.. I want to personally thank Doug and Dave For making the 1500 mg Balm personally for me. At first it was just a test to see if it was better than the 500 mg because the 500 mg is the best thing that I have ever used for pain topically prescription or otherwise but the 1500 mg was like heaven They made 50 more of them and I sold all of them in a month. I sell the 500 almost as easily as I sell the dog treats because of the balm I have patients who tell me that I have changed their life by recommending this topical wonder and I’m not kidding this stuff really works and it smells good you don’t end up smelling like icy hot you just apply it and massage it in a matter of minutes you get relief … if you’re a pharmacy owner choose a company that is pharmacy first. If youre a patient choose viridipharm and go to an independent pharmacy that recommends viridipharm. You have access to the pharmacist knowledge about CBD and know that he or she spent the time to research Viridipharm…. it is truly awesome to have direct access to company. If you have questions for me my cell is 704-400-8852. Go Heels!

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